In most cases, the therapeutic serum lithium levels were less than or equal to 1.5 mEq/L ( P < .001), and dosage regimens were less than 2,000 mg/day. Most patients had affective disorders, schizoaffective disorders, and/or depression ( P < .001) and presented mainly with acute organic brain syndrome. Publications cited include articles concerned with reversible lithium neurotoxicity.ĭata Extraction: The age, sex, clinical features, diagnostic categories, lithium doses, serum lithium levels, precipitating factors, and preventive measures of 52 cases of reversible lithium neurotoxicity were extracted.ĭata Synthesis: Among the 52 cases of reversible lithium neurotoxicity, patients ranged in age from 10 to 80 years and a greater number were female ( P = .008). Study Selection: A combination of the following search terms was used: lithium AND adverse effects AND central nervous system OR neurologic manifestation. ![]() MEDLINE and PsycINFO were searched by using the OvidSP interface. This review aims to study the clinical presentation of cases of reversible lithium neurotoxicity.ĭata Sources: A comprehensive electronic search was conducted in the following databases: MEDLINE (PubMed), 1950 to November 2010 PsycINFO, 1967 to November 2010 and SCOPUS (EMBASE), 1950 to November 2010. Cases of reversible lithium neurotoxicity differ in clinical presentation from those of irreversible lithium neurotoxicity and have important implications in clinical practice. ![]() ![]() Reversible lithium neurotoxicity has been defined as cases of lithium neurotoxicity in which patients recovered without any permanent neurologic sequelae, even after 2 months of an episode of lithium toxicity. Objective: Lithium neurotoxicity may be reversible or irreversible.
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